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Amniocentesis carries various risks, including:

• Miscarriage. Second-trimester amniocentesis carries a slight risk of miscarriage — between 1 in 300 and 1 in 500. Research suggests that the risk of miscarriage is higher for amniocentesis done before 15 weeks of pregnancy.
• Needle injury. During amniocentesis the baby might move an arm or leg into the path of the needle. Serious needle injuries are rare.
• Leaking amniotic fluid. Rarely, amniotic fluid leaks through the vagina after amniocentesis. If the leak seals, the pregnancy is likely to proceed normally. It's possible, however, for chronic leakage to lead to orthopedic problems for the baby.
• Rh sensitization. Rarely, amniocentesis might cause the baby's blood cells to enter the mother's bloodstream. If you have Rh negative blood, you'll be given a drug called Rh immunoglobulin after amniocentesis to prevent you from producing antibodies against your baby's blood cells.
• Infection. Rarely, amniocentesis might trigger a uterine infection.
• Infection transmission. If you have an infection — such as hepatitis C, toxoplasmosis or human immunodeficiency virus — the infection might be transferred to your baby during amniocentesis.

Remember, genetic amniocentesis is typically offered when the test results might have a significant impact on management of the pregnancy. Ultimately, the decision to have genetic amniocentesis is up to you. Your health care provider or genetic counselor can help you weigh all the factors in the decision.

Maturity amniocentesis is often suggested when early delivery would be best for the mother. With minimal risks, maturity amniocentesis can offer assurance that the baby is ready for birth.

If you're having amniocentesis done before week 20 of pregnancy, your bladder must be full during the procedure. Drink plenty of fluids before your appointment. After 20 weeks of pregnancy, your bladder must be empty during amniocentesis.

Your health care provider might ask you to sign a consent form before the procedure begins. Consider asking someone to accompany you to the appointment for emotional support or to drive you home afterward.

Amniocentesis is usually done in an outpatient facility or the health care provider's office.

During the procedure

First, your health care provider will use ultrasound to determine the baby's exact location in your uterus. You'll lie on your back on an exam table and expose your abdomen. Your health care provider will apply a special gel to your abdomen and then use a small device known as an ultrasound transducer to show your baby's position on a monitor.

Next, your health care provider will clean your abdomen with an antiseptic. Generally, anesthetic isn't used. Most women report only mild discomfort during the procedure.

Guided by ultrasound, your health care provider will insert a thin, hollow needle through your abdominal wall and into the uterus. A small amount of amniotic fluid will be withdrawn into a syringe, and the needle will be removed. The specific amount of amniotic fluid withdrawn depends on the number of weeks the pregnancy has progressed.

You'll need to lie still while the needle is inserted and the amniotic fluid is withdrawn. You might notice a stinging sensation when the needle enters your skin, and you might feel cramping when the needle enters your uterus. The procedure usually takes about 20 to 30 minutes.

After the procedure

After the amniocentesis, your health care provider might use ultrasound to monitor your baby's heart rate. You might experience cramping or a small amount of vaginal bleeding immediately after the amniocentesis. Avoid strenuous physical activity for a day or two.

Meanwhile, the sample of amniotic fluid will be analyzed in a lab. Some results might be available within a few days. Other results might take up to four weeks.

Contact your health care provider if you have:

• Persistent fluid leaking from your vagina
• Heavy vaginal bleeding
• Abdominal pain or uterine cramping that lasts more than a few hours
• Fever
• Redness and inflammation where the needle was inserted
• Unusual fetal activity or a lack of fetal movement

Your health care provider or a genetic counselor will help you understand your amniocentesis results.

For genetic amniocentesis, test results can reliably rule out or diagnose various genetic conditions, such as Down syndrome. Amniocentesis can't identify all birth defects, however.

If amniocentesis indicates that your baby has a chromosomal or genetic condition that can't be treated, you might face wrenching decisions — such as whether to continue the pregnancy. Seek support from your health care team and your loved ones during this difficult time.

For maturity amniocentesis, test results can reliably indicate a baby's lung maturity. If you need to deliver the baby early, this information offers reassurance that your baby is ready for birth.