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As with any screening test, an HPV test carries the risk of false-positive or false-negative results.

• False-positive. A false-positive test result indicates that you have a high-risk type of HPV when you really don't. A false-positive result could lead to an unnecessary follow-up procedure, such as colposcopy or biopsy, and undue anxiety over the test results.
• False-negative. A false-negative test result means you really do have an HPV infection, but the test indicates that you don't. This might cause a delay in appropriate follow-up tests or procedures.

No special preparation is necessary before you have an HPV test. However, since an HPV test often is done at the same time as a Pap test, you can take these measures to make both tests as accurate as possible:

• Avoid intercourse, douching, or using any vaginal medicines or spermicidal foams, creams or jellies for two days before the test.
• Try not to schedule the test during your menstrual period. The test can be done, but your doctor can collect a better sample of cells at another time in your cycle.

An HPV test is usually done at the same time as a Pap test — a test that collects cells from your cervix to check for abnormalities or the presence of cancer. An HPV test can be done using the same sample from the Pap test or by collecting a second sample from the cervical canal.

During the HPV test

A combination Pap-HPV test is performed in your doctor's office and takes only a few minutes. You may be asked to undress completely or only from the waist down.

You'll lie on your back on an exam table with your knees bent. Your heels rest in supports called stirrups.

Your doctor will gently insert an instrument called a speculum into your vagina. The speculum holds the walls of the vagina apart so that your doctor can easily see your cervix. Inserting the speculum may cause a sensation of pressure in your pelvic area. Sometimes the speculum feels cold when it's first inserted.

Then your doctor will take samples of your cervical cells using a soft brush and a flat scraping device called a spatula. This doesn't hurt, and you may not even feel the sample being taken.

After the HPV test

After your test, you can go about your normal daily activities without any restrictions. Ask your doctor about when you can expect to receive your test results.

Results from your HPV test will come back as either positive or negative.

• Positive HPV test. A positive test result means that you have a type of HPV that's linked to cervical cancer. It doesn't mean that you have cervical cancer now, but it's a warning sign that cervical cancer could develop in the future. Your doctor will probably recommend a follow-up test in six months to a year to see if the infection has cleared or to check for signs of cervical cancer.
• Negative HPV test. A negative test result means that you don't have any of the types of HPV that cause cervical cancer.

Depending on your test results, your doctor may recommend one of the following as a next step:

• Normal monitoring. If you're over age 30, your HPV test is negative and your Pap test normal, you'll follow the generally recommended schedule for repeat testing in three years.
• Colposcopy. In this follow-up procedure, your doctor uses a special magnifying lens (colposcope) to more closely examine your cervix.
• Biopsy. In this procedure, sometimes done in conjunction with colposcopy, your doctor takes a sample of cervical cells (biopsy) to be examined more closely under a microscope.
• Removal of abnormal cervical cells. To prevent abnormal cells from developing into cancerous cells, your doctor may suggest a procedure to remove the areas of tissue that contain the abnormal cells.
• Seeing a specialist. If your Pap test or HPV test results are abnormal, your health care provider will probably refer you to a gynecologist for a colposcopic exam. If test results show that you might have cancer, you may be referred to a doctor who specializes in treating cancers of the female genital tract (gynecologic oncologist) for treatment.